Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000167)
SBP Name
Peptide aptamer anti-CE Pi-101
Synonyms
Peptide aptamer Pi-101
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method cDNA display
Highest Status Research
SBP Sequence
>Variable region
SCGGIIIISCIA
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS051
Scaffold Info
[1] , [2]
Scaffold Name Peptide aptamer
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Cathepsin E
BTS Info
Inhibitor Tools for protein function modulation Kd: 62 nM Saitama Industrial Technology Center; Saitama University [1] , [2]
References
1 Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E. J Mol Biol. 2009 Apr 17;387(5):1186-98.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.