Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00251)
BTS Name
Cathepsin E
Synonyms
EC 3.4.23.34
BTS Type
Protein
Family
Peptidase A1 family
Gene Name
Ctse
Organism
Rattus norvegicus (Rat)
Function
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain (By similarity).
UniProt ID
P16228
UniProt Entry
CATE_RAT
PFam
PF07966 ; PF00026
Gene ID
25424
Sequence
MKPLFVLLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSE
SCNVDKGINEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSPACKAHP
VFHPSQSSTYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVN
AEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDP
SHFSGSLNWIPVTKQGYWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQ
EAIGATPMDGEYAVDCATLNMMPNVTFLINGVSYTLSPTAYILPDLVDGMQFCGSGFQGL
DIQPPAGPLWILGDVFIRKFYSVFDRGNNQVGLAPAVP
Sequence Length
398
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Peptide aptamer anti-CE Pi-101 Research Inhibitor Kd: 62 nM Tools for protein function modulation
SBP Info
 		[1], [2]
References
1 Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E. J Mol Biol. 2009 Apr 17;387(5):1186-98.
2 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.