General Information of Synthetic Binding Protein (SBP) (ID: SBP000121)
SBP Name
DARPin anti-CASP-3 D3.4S76R
Synonyms
DARPin D3.4S76R
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Hela cells
Selection Method Ribosome display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS027
Scaffold Info
[1]
Scaffold Name DARPin
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Caspase-3
BTS Info
Inhibitor Research tool N.A. University of Zurich [1]
References
1 Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise. Biochem J. 2014 Jul 15;461(2):279-90.