Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00127) | ||||||
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| BTS Name |
Caspase-3
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| Synonyms |
CASP-3; EC 3.4.22.56; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
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| BTS Type |
Protein
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| Family |
Peptidase C14A family
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| Gene Name |
CASP3
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| Organism |
Homo sapiens (Human)
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| Function |
Involved in the activation cascade of caspases responsible for apoptosis execution At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 Involved in the cleavage of huntingtin Triggers cell adhesion in sympathetic neurons through RET cleavage Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| Gene ID | ||||||
| Sequence |
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH |
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| Sequence Length |
277
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| DARPin anti-CASP-3 D3.4S76R | Research | Inhibitor | N.A. | Research tool | [1] | |