General Information of Synthetic Binding Protein (SBP) (ID: SBP000097)
SBP Name
Anticalin anti-CTLA-4 Lcn2m6
Synonyms
Anticalin Lcn2m6
Molecular Weight 23.6 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Escherichia coli display and Fluorescence-activated cell sorting
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS011
Scaffold Info
[1]
Scaffold Name Anticalin
Scaffold Class Non-Antibody
Fold Type One Alpha-Helix + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Cytotoxic T-lymphocyte protein 4
BTS Info
Blocker Research tool Kd: 600 nM Technical University of Munich [1]
References
1 High-throughput sorting of an Anticalin library via EspP-mediated functional display on the Escherichia coli cell surface. J Mol Biol. 2010 Jul 23;400(4):783-802.