General Information of Synthetic Binding Protein (SBP) (ID: SBP000064)
SBP Name
Anticalin anti-CTLA-4 PRS-010
Synonyms
Anticalin PRS-010
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS011
Scaffold Info
[1]
Scaffold Name Anticalin
Scaffold Class Non-Antibody
Fold Type One Alpha-Helix + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Cytotoxic T-lymphocyte protein 4
BTS Info
Binder Cancers [ICD-11: 2D4Z] N.A. Pieris AG [1]
References
1 Challenges and opportunities for non-antibody scaffold drugs. Drug Discov Today. 2015 Oct;20(10):1271-83.