Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00582)
BTS Name
GTPase NRas
Synonyms
EC:3.6.5.2; Transforming protein N-Ras
BTS Type
Protein
Family
small GTPase superfamily;
Ras family
Gene Name
NRAS
Organism
Homo sapiens (Human)
Function
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
UniProt ID
P01111
UniProt Entry
RASN_HUMAN
PFam
PF00071
Gene ID
4893
Sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM
Sequence Length
189
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Monobody anti-HRAS/NRAS/KRAS JAM20 Research Inhibitor Kd: 5 nM Tumors [ICD-11: XH1N44]
SBP Info
 		[1]
Monobody anti-HRAS/NRAS/KRAS JAM20 Research Inhibitor Kd: 21 nM Tumors [ICD-11: XH1N44]
SBP Info
 		[1]
Monobody anti-HRAS/NRAS/KRAS R15 Research Inhibitor Kd: 219 nM Tools for inhibition of selected oncogenic RAS mutants
SBP Info
 		[2]
References
1 Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2204481119.
2 Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants. Cell Rep. 2022 Feb 8;38(6):110322.