General Information of Binding Target of SBP (BTS) (ID: ST00556)
BTS Name
Integrin alpha-v-beta-6
BTS Type
Protein
Family
Integrin alpha chain family;
Integrin beta chain family
Organism
Homo sapiens (Human)
UniProt ID
P06756, P18564
UniProt Entry
ITAV_HUMAN, ITB6_HUMAN
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Knottin anti-Integrin R(O)1 Research Binder Kd: 3.6 nM Tools for detecting pancreatic cancer
SBP Info
[1]
Knottin anti-Integrin R(O)2 Research Binder Kd: 3.2 nM Tools for detecting pancreatic cancer
SBP Info
[1]
Knottin anti-Integrin R(O)3 Research Binder Kd: 3.2 nM Tools for detecting pancreatic cancer
SBP Info
[1]
Knottin anti-Integrin S(O)1 Research Binder Kd: 6.5 nM Tools for detecting pancreatic cancer
SBP Info
[1]
Knottin anti-Integrin S(O)2 Research Binder Kd: 6 nM Tools for detecting pancreatic cancer
SBP Info
[1]
Knottin anti-Integrin S(O)3 Research Binder Kd: 3.1 nM Tools for detecting pancreatic cancer
SBP Info
[1]
References
1 Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer. Clin Cancer Res. 2012 Feb 1;18(3):839-49.