Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000530) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Knottin anti-Integrin R(O)2
|
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| Synonyms |
Knottin R(O)2
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| Molecular Weight | 3.9 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Saccharomyces cerevisiae EBY100 | |||||
| Selection Method | Yeast display | |||||
| Highest Status | Research | |||||
| Sequence Length | 36 | |||||
| SBP Sequence |
>Knottin anti-Integrin R(O)2
GCRSLARTDLDHLRGRCRRDSDCPGACICRGNGYCG |
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| Sequence Description | Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds. | |||||
| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS042 | [1] | ||||
| Scaffold Name | Knottin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Integrin alpha-v-beta-6 | Binder | Tools for detecting pancreatic cancer | Kd: 3.2 nM | Stanford University School of Medicine | [1] | |