General Information of Synthetic Binding Protein (SBP) (ID: SBP000533)
SBP Name
Knottin anti-Integrin S(O)2
Synonyms
Knottin S(O)2
Molecular Weight 3.9 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Saccharomyces cerevisiae EBY100
Selection Method Yeast display
Highest Status Research
Sequence Length 36
SBP Sequence
>Knottin anti-Integrin S(O)2
GCRSLARTDLDHLRGRCSSDSDCLAECICLENGFCG
Sequence Description Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds.
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS042
Scaffold Info
[1]
Scaffold Name Knottin
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Integrin alpha-v-beta-6
BTS Info
Binder Tools for detecting pancreatic cancer Kd: 6 nM Stanford University School of Medicine [1]
References
1 Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer. Clin Cancer Res. 2012 Feb 1;18(3):839-49.