General Information of Binding Target of SBP (BTS) (ID: ST00554)
BTS Name
Integrin alpha-v-beta-5
BTS Type
Protein
Family
Integrin alpha chain family;
Integrin beta chain family
Organism
Homo sapiens (Human)
UniProt ID
P06756, P18084
UniProt Entry
ITAV_HUMAN, ITB5_HUMAN
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Knottin anti-Integrin EETI-1.5B Research Binder N.A. Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Knottin anti-Integrin EETI-2.5D Research Binder N.A. Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Knottin anti-Integrin EETI-2.5F Research Binder N.A. Glioma [ICD-11: 2A00.0]
SBP Info
[1]
Tendamistat-based binder anti-Integrin variants Research Binder N.A. Research tool
SBP Info
[2]
References
1 Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity. Proteins. 2009 Nov 1;77(2):359-69.
2 Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Eng. 2003 Jan;16(1):65-72.