Details of the BTS | SYNBIP

General Information of Binding Target of SBP (BTS) (ID: ST00422)
BTS Name	DNA
Synonyms	DNA
BTS Type	DNA
Organism	Bos taurus (Bovine)

Synthetic Binding Protein (SBP) Targeting This BTS

SBP Name	Highest Status	Mechanism	Affinity	Application	Details	Ref
Affitin anti-DNA/HEWL mL3	Research	Binder	Kd: 62500 nM	Research tool	SBP Info	[1]
Fab anti-Ars-Tyr/DNA Arg-Gly VH mutant	Research	Binder	N.A.	Diagnostic reagent; Therapeutic application	SBP Info	[2]
Fab anti-Ars-Tyr/DNA Arg-Ser VH mutant	Research	Binder	N.A.	Diagnostic reagent; Therapeutic application	SBP Info	[2]
Fab anti-Ars-Tyr/DNA Asp-Arg VH mutant	Research	Binder	N.A.	Diagnostic reagent; Therapeutic application	SBP Info	[2]
Fab anti-Ars-Tyr/DNA Ser-Arg VH mutant	Research	Binder	N.A.	Diagnostic reagent; Therapeutic application	SBP Info	[2]
Zinc finger domain anti-DNA variants	Research	Binder	N.A.	Research tool	SBP Info	[3], [4]

References

1	Affinity transfer to the archaeal extremophilic Sac7d protein by insertion of a CDR. Protein Eng Des Sel. 2014 Oct;27(10):431-8.
2	Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen. J Exp Med. 1995 Sep 1;182(3):743-50.
3	Structure-based DNA-binding prediction and design. Methods Mol Biol. 2010;649:77-88.
4	An improved strategy for constructing "designer" Cys2His2 zinc finger proteins. Discov Med. 2003 Dec;3(19):32-5.