Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00321) | ||||||
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| BTS Name |
Complement C3
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| Synonyms |
C3bc; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
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| BTS Type |
Protein
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| Gene Name |
C3
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| Organism |
Cavia porcellus (Guinea pig)
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| Function |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity).; [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MGPAAGPSLLLLLLASVSLALGDPMYSIITPNILRLENEETVVLEAHEVQGDIPVTVTVH
DFPAKKNVLSSEKTVLTSATGYLGTVTIKIPASKEFKSDKGRKLVVVQAAFGGTQLEKVV LVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVDSDLLPVGRTIIVTIETPDGIPIKRDTLS SNNQHGILPLSWNIPELVNMGQWKIQAFYENSPKQVFSAEFEVKEYVLPSFEVLVEPTEK FYYIDDPKGLEVNIIARFLYGKNVDGTAFVIFGVQDGDQRISLAQSLTRVVIEDGSGEVV LSRQVLLDGVQPSRPEALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKTP KYFKPAMPFEIMVLVTNPDGSPAPHVPVVTQGSNVQSLTQADGVARLSINTPNTRQPLSV TVQTKKGGIPDARQAINTMQALPYTTMYNSNNYLHLSMPRTELKPGETINVNFHLRSDPN QEAKIRYYTYLIMNKGKLLKVGRQPREPGQALVVLPMPITKELIPSFRLVAYYTLIGASA QREVVADSVWADVRDSCVGTLVVKGGSGKDGQDKRQQHLPRQQMTLRIEGNQGARVGLVA VDKGVFVLNKKHKLTQSKIWDVVEKADIGCTPGSGKDYAGVFTDAGLSFKSSKAGLQTAQ REGLDCPKPAARRRRSVQLMERRMDKAGKYKSKELRRCCEDGMRENPMQFSCQRRARYVS LGEACVKAFLDCCTYMAQLRQQHRREQNLGLARSDMDEDIIPEEDIISRSQFPESWLWTI EELKEPERNGISTKTMNIFLKDSITTWEILAVSLSDKKGICVADPFEVTVMQDFFIDLRL PYSVVRNEQVEIRAVLYNYREAQSLKVRVELLHNPAFCSLATAKKRHTQTVTIGPKSSVA VPYVLVPLKIGLQEVEVKAAVYNYFISDGVKKTLKVVPEGMRVNKTVAIRTLNPEQLGQG GVQREEIPAADLSDQVPDTDSETKILLQGTPVAQMAEDAVDAERLKHLIITPSGCGEQNM IGMTPTVIAVHYLDQTEQWEKFGLEKRQEALNLINRGYTQQLAFKQPNWAYAAFKNRASS TWLTAYVVKVFSLAANLIGIDSEVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGVRT AQEADVSLTAFVLIALQEAKDICRAQVNNLEANINKAGDYIESRYADVRRPYTLAIAGYA LALLERLNGATLQKFLNAATEKNRWEEARQKLYSVEATSYALLALLLLKDFDAVPPVVRW LNEQRYYGRGYGSTQATFMVFQALAQYQTDVPDHKDLNMEVALQLPSRSSPSKFRLVWEA GSLLRSEATKQNEGFKLTAKGKGQGTLSVVAVYYAKTKRKVVCKNFDLRVTLKPAPDTVK KPQEAKSTMILGICTRYLGDQDATMSILDISMMTGFIPDTDDLKLLATGVDRYISKYEMN KDFSKNTLIIYLDKVSHSEEECLSFKIHQFFNVGLIQPGSVKVYSYYNLDETCTQFYHPE KEDGMLNKLCHKDLCRCAEENCFIQLPEKITLDERLEKACEPGVDYVYKTKLLKMELSDD FDEYIMTIEQVIKSGSDEVQAGKERRFISHIKCRDALHLKEGKHYLMWGLSSDLWGERPN MSYIIGKDTWVEAWPEAEECQDEENQQQCQDLGTFTENMVVFGCPN |
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| Sequence Length |
1666
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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| scFv anti-C3 BA8 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 BD12 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 BD3 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 KA8 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 KC11 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 KC3 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 KE11 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 KF7 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 KG3 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 MA11 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 MA9 | Research | Binder | N.A. | Research tool | [1] | |
| scFv anti-C3 MF9 | Research | Binder | N.A. | Research tool | [1] | |