Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00291)
BTS Name
Endoglin
Synonyms
CD antigen CD105
BTS Type
Protein
Gene Name
ENG
Organism
Homo sapiens (Human)
Function
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis Required for normal structure and integrity of adult vasculature Regulates the migration of vascular endothelial cells Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3
UniProt ID
P17813
UniProt Entry
EGLN_HUMAN
PFam
PF00100
Gene ID
2022
Sequence
MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNA
ILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAY
NSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLS
FCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVEL
SCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLL
GEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQ
TKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASM
ISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVS
PSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVP
IPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAF
LIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA
Sequence Length
658
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
scFv anti-CD105 A5 Research Binder Kd: 700 nM Tools for the generation of vascular or tumor targeting agents in cancer therapy
SBP Info
 		[1]
scFv anti-CD105 B11 Research Binder N.A. Research tool
SBP Info
 		[1]
scFv anti-CD105 C4 Research Binder N.A. Research tool
SBP Info
 		[1], [2]
scFv anti-CD105 E1.3 Research Binder N.A. Research tool
SBP Info
 		[1]
scFv anti-CD105 E1.5 Research Binder N.A. Research tool
SBP Info
 		[1]
References
1 Isolation of endothelial cell-specific human antibodies from a novel fully synthetic scFv library. Biochem Biophys Res Commun. 2004 Apr 30;317(2):515-21.
2 Targeting of adenovirus to endothelial cells by a bispecific single-chain diabody directed against the adenovirus fiber knob domain and human endoglin (CD105). Mol Ther. 2001 Jun;3(6):882-91.