Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001716)
SBP Name	scFv anti-CD105 A5
Synonyms	scFv A5
Molecular Weight	25.6 kDa
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli TG1
Selection Method	Phage display
Highest Status	Research
Sequence Length	241
SBP Sequence	>scFv anti-CD105 A5 EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIYGSDGDTTY ADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARVFYTAGFDYWGQGTLVTVSSGS DANAGRASAGNTSDIELTQSPSSLSASVGDRVTITCRASQSISSSLNWYQQKPGKAPKLL IYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQAPAKPPTFGQGTKLEIK R
3D Structure
	Computationally Modelled Structure
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Template Name	Variable germline segments DP47 and DPkappa9

Protein Scaffold Information of This SBP
Scaffold ID	PS057 Scaffold Info					[1]
Scaffold Name	scFv
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Endoglin	BTS Info	Binder	Tools for the generation of vascular or tumor targeting agents in cancer therapy	Kd: 700 nM	University of Marburg	[1]

References

1

Isolation of endothelial cell-specific human antibodies from a novel fully synthetic scFv library. Biochem Biophys Res Commun. 2004 Apr 30;317(2):515-21.