Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00282)
BTS Name
Matrix protein VP40
Synonyms
Ebola VP40; eVP40; Membrane-associated protein VP40
BTS Type
Protein
Family
Filoviridae matrix protein VP40 family
Gene Name
VP40
Organism
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
Function
Plays an essential role virus particle assembly and budding Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101 The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis)
UniProt ID
Q05128
UniProt Entry
VP40_EBOZM
PFam
PF07447
Gene ID
911825
Sequence
MRRVILPTAPPEYMEAIYPVRSNSTIARGGNSNTGFLTPESVNGDTPSNPLRPIADDTID
HASHTPGSVSSAFILEAMVNVISGPKVLMKQIPIWLPLGVADQKTYSFDSTTAAIMLASY
TITHFGKATNPLVRVNRLGPGIPDHPLRLLRIGNQAFLQEFVLPPVQLPQYFTFDLTALK
LITQPLPAATWTDDTPTGSNGALRPGISFHPKLRPILLPNKSGKKGNSADLTSPEKIQAI
MTSLQDFKIVPIDPTKNIMGIEVPETLVHKLTGKKVTSKNGQPIIPVLLPKYIGLDPVAP
GDLTMVITQDCDTCHSPASLPAVIEK
Sequence Length
326
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
scFv anti-VP40 DSTL094 Research Binder N.A. Tools for detecting Ebolavirus infection
SBP Info
 		[1]
scFv anti-VP40 DSTL095 Research Binder N.A. Tools for detecting Ebolavirus infection
SBP Info
 		[1]
References
1 Isolation and characterisation of Ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries. Mol Immunol. 2011 Sep;48(15-16):2027-37.