General Information of Binding Target of SBP (BTS) (ID: ST00277)
BTS Name
Urease subunit alpha
Synonyms
EC 3.5.1.5; Urea amidohydrolase subunit alpha
BTS Type
Protein
Family
Urease gamma subunit family;
Urease beta subunit family
Gene Name
ureA
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function
Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach.
UniProt ID
P14916
UniProt Entry
URE23_HELPY
PFam
PF00699 ; PF00547
Sequence
MKLTPKELDKLMLHYAGELAKKRKEKGIKLNYVEAVALISAHIMEEARAGKKTAAELMQE
GRTLLKPDDVMDGVASMIHEVGIEAMFPDGTKLVTVHTPIEANGKLVPGELFLKNEDITI
NEGKKAVSVKVKNVGDRPVQIGSHFHFFEVNRCLDFDREKTFGKRLDIASGTAVRFEPGE
EKSVELIDIGGNRRIFGFNALVDRQADNESKKIALHRAKERGFHGAKSDDNYVKTIKE
Sequence Length
238
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
scFv anti-urease B4 Research Inhibitor Kd: 17 nM Helicobacter pylori [ICD-11: XN3DY]
SBP Info
[1]
scFv anti-urease D9 Research Inhibitor Kd: 42 nM Research tool
SBP Info
[1]
References
1 Selection of human single chain Fv antibody fragments binding and inhibiting Helicobacter pylori urease. Tumour Biol. Jan-Feb 2001;22(1):36-44.