Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001761) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
scFv anti-urease D9
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| Synonyms |
scFv D9
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| SBP Sequence |
>VH Chain
QVQLQQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISYNGNTNYA QKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARGRGGDYYYYYGMDVWGQGTTVTV S >VL Chain SSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPLLVIYGETNRPSGIPDR FSGSSSGNTASLTITGAQAEDEADYYCQVWRSDQGIFGGGTKLTVLGA |
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| Template Name | VH3 DP14 and Vgamma3 DPL16 | |||||
| Template Sequence |
>VH3 DP14
QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISYNGNTNYA QKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCAR >Vgamma3 DPL16 SSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDR FSGSSSGNTASLTITGAQAEDEADYYCNSRDSSGNH |
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| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS057 | [1] | ||||
| Scaffold Name | scFv | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
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| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Urease subunit alpha | Inhibitor | Research tool | Kd: 42 nM | University of Lausanne | [1] | |