Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP001760) | ||||||
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SBP Name |
scFv anti-urease B4
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Synonyms |
scFv B4
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Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Expression System | Escherichia coli | |||||
Selection Method | Phage display | |||||
Highest Status | Research | |||||
SBP Sequence |
>VH Chain
QVQLQESGGGVVQPGRSLRLSCARSGFSFSSYGMHWVRQAPGKGLEWVAVISYDGNNKYY ADSVKGRFTISRDNSKNTLYLQMNSLRAGDTAVYYCAKPYGDIAMVLIDAFDIWGQGTMV TVS >VL Chain SSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPLLVIYGENNRPSGIPDR FSGSSSGNTASLTITGAQAEDEADYYCHTYLRV FGGGTKLTVLGA |
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Template Name | VH3 DP49 and Vgamma3 DPL16 | |||||
Template Sequence |
>VH3 DP49
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGSNKYY ADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAK >Vgamma3 DPL16 SSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDR FSGSSSGNTASLTITGAQAEDEADYYCNSRDSSGNH |
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Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS057 | [1] | ||||
Scaffold Name | scFv | |||||
Scaffold Class | Antibody fragment | |||||
Fold Type | Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Urease subunit alpha | Inhibitor | Helicobacter pylori [ICD-11: XN3DY] | Kd: 17 nM | University of Lausanne | [1] | |