Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00227) | ||||||
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| BTS Name |
Lactose permease
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| Synonyms |
Lactose-proton symport
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| BTS Type |
Protein
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| Family |
Major facilitator superfamily;
Oligosaccharide:H(+) symporter (OHS) (TC 2.A.1.5) family |
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| Gene Name |
lacY
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| Organism |
Escherichia coli (strain K12)
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| Function |
Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl-1-thio-beta,D-galactopyranoside (TMG), but not sucrose or fructose The substrate specificity is directed toward the galactopyranosyl moiety of the substrate
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQ
PLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNA GAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALIL AVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFD QQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMS VRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQL AMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLRRQVNEVA |
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| Sequence Length |
417
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Nanobody anti-Lactose permease clone 9039 | Research | Binder | Kd: 15000 nM | Tools for stabilizing this state of the protein | [1] | |
| Nanobody anti-Lactose permease clone 9047 | Research | Binder | Kd: 5300 nM | Research tool | [2] | |