Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00220) | ||||||
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| BTS Name |
Dipeptide and tripeptide permease A
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| BTS Type |
Protein
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| Family |
Major facilitator superfamily;
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family; DtpA subfamily |
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| Gene Name |
dtpA
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| Organism |
Escherichia coli (strain K12)
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| Function |
Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
TLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMA AIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWS VAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLN FFAIRNVEHSILGLAVEPEQYQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMC SGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIM GSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP KLHRMTQDDAADKAAKAAVA |
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| Sequence Length |
500
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Nanobody anti-DtpA N00 | Research | Binder | Kd: 59000 nM | Research tool | [1] | |
| Nanobody anti-DtpA N21 | Research | Binder | N.A. | Research tool | [1] | |
| Nanobody anti-DtpA N87 | Research | Binder | N.A. | Research tool | [1] | |
| Nanobody anti-DtpA N89 | Research | Binder | N.A. | Research tool | [1] | |
| Nanobody anti-DtpA N93 | Research | Binder | N.A. | Research tool | [1] | |