General Information of Synthetic Binding Protein (SBP) (ID: SBP001091)
SBP Name
Nanobody anti-DtpA N21
Synonyms
Nanobody N21
Molecular Weight 12.6 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli WK6
Selection Method Phage display
Highest Status Research
Sequence Length 117
SBP Sequence
>Nanobody anti-DtpA N21
QVQLQESGGGLVQPGGSLRLSCAASGRIPFITAMGWYRQAPGRQRELLATVTNSGSTNYA
DSVKGRFTISRDNAKNTVSLQMNSLKAEDTAVYYCNVRRLGNLSDYWGQGTQVTVSS
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Dipeptide and tripeptide permease A
BTS Info
Binder Research tool N.A. Centre for Structural Systems Biology (CSSB) [1]
References
1 Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1. J Am Chem Soc. 2019 Feb 13;141(6):2404-2412.