Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00210) | ||||||
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| BTS Name |
Vitamin B12-binding protein
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| BTS Type |
Protein
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| Family |
BtuF family
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| Gene Name |
btuF
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| Organism |
Escherichia coli (strain K12)
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| Function |
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MAKSLFRALVALSFLAPLWLNAAPRVITLSPANTELAFAAGITPVGVSSYSDYPPQAQKI
EQVSTWQGMNLERIVALKPDLVIAWRGGNAERQVDQLASLGIKVMWVDATSIEQIANALR QLAPWSPQPDKAEQAAQSLLDQYAQLKAQYADKPKKRVFLQFGINPPFTSGKESIQNQVL EVCGGENIFKDSRVPWPQVSREQVLARSPQAIVITGGPDQIPKIKQYWGEQLKIPVIPLT SDWFERASPRIILAAQQLCNALSQVD |
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| Sequence Length |
266
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Nanobody anti-BtuF clone 10 | Research | Inhibitor | Kd: 6 nM | Research tool | [1] | |
| Nanobody anti-BtuF clone 7 | Research | Inhibitor | Kd: 24 nM | Research tool | [1] | |
| Nanobody anti-BtuF clone 9 | Research | Inhibitor | Kd: 0.94 nM | Research tool | [1] | |