Details of the BTS
General Information of Binding Target of SBP (BTS) (ID: ST00204) | ||||||
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BTS Name |
Small ubiquitin-related modifier 1
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Synonyms |
SUMO-1; GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein UBL1
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BTS Type |
Protein
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Family |
Ubiquitin family;
SUMO subfamily |
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Gene Name |
SUMO1
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Organism |
Homo sapiens (Human)
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Function |
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3
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UniProt ID | ||||||
UniProt Entry | ||||||
PFam | ||||||
Gene ID | ||||||
Sequence |
MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMN
SLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV |
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Sequence Length |
101
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Synthetic Binding Protein (SBP) Targeting This BTS |
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SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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Monobody anti-hSUMO1 clone 1 | Research | Inhibitor | Kd: 652 nM | Research tool | [1] | |
Monobody anti-hSUMO1 clone 2 | Research | Inhibitor | Kd: 290 nM | Research tool | [1] | |
Monobody anti-hSUMO1 clone 3 | Research | Inhibitor | Kd: 519 nM | Research tool | [1] | |
Monobody anti-hSUMO1 clone 4 | Research | Inhibitor | Kd: 118 nM | Research tool | [1] | |
Monobody anti-hSUMO1 clone 5 | Research | Inhibitor | Kd: 284 nM | Research tool | [1] | |
Monobody anti-hSUMO1 clone 9 | Research | Inhibitor | Kd: 738 nM | Research tool | [1] | |
Monobody anti-hSUMO1 SL13 | Research | Binder | Kd: 270 nM | Tools for identifying the unanticipated mode of monobody-target interactions | [2] | |
Monobody anti-hSUMO1 SL14 | Research | Binder | Kd: 179 nM | Tools for identifying the unanticipated mode of monobody-target interactions | [2] | |
Monobody anti-hSUMO1 SL8 | Research | Binder | Kd: 10 nM | Tools for identifying the unanticipated mode of monobody-target interactions | [2] | |
Monobody anti-hSUMO1 SS18 | Research | Binder | Kd: 114 nM | Tools for identifying the unanticipated mode of monobody-target interactions | [2] | |
Monobody anti-hSUMO1 SS20 | Research | Binder | Kd: 748 nM | Tools for identifying the unanticipated mode of monobody-target interactions | [2] | |
Monobody anti-SUMO clone 1 | Research | Inhibitor | Kd: 54000 nM | Research tool | [3], [1] | |
References |
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