Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000028)
SBP Name
Monobody anti-hSUMO1 clone 2
Synonyms
hS1MB-2
Molecular Weight 10.1 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
Sequence Length 97
SBP Sequence
>Monobody anti-hSUMO1 clone 2
GSSVSSVPTKLEVVAATPTSLLISWDASSSSVSHYGITYGETGGNSPVQEFTVPGSSSTA
TISGLSPGVDYTITVYAYHSYDDIYYALSPSSINYRT
3D Structure
Computationally Modelled Structure
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Template Name ySMB-1
Protein Scaffold Information of This SBP
Scaffold ID PS047
Scaffold Info
[1]
Scaffold Name Monobody
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Small ubiquitin-related modifier 1
BTS Info
Inhibitor Research tool Kd: 290 nM University of Chicago [1]
References
1 Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7751-6.