Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00202)
BTS Name
T-lymphocyte activation antigen CD80
Synonyms
Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD antigen CD80
BTS Type
Protein
Gene Name
CD80
Organism
Homo sapiens (Human)
Function
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.; (Microbial infection) Acts as a receptor for adenovirus subgroup B.
UniProt ID
P33681
UniProt Entry
CD80_HUMAN
PFam
PF08205 ; PF07686
Gene ID
941
Sequence
MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELA
QTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLK
YEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGE
ELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFP
DNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
Sequence Length
288
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Monobody anti-B7.1 CFN13 Research Inhibitor N.A. Research tool
SBP Info
 		[1]
VL dAb anti-B7.1 MB10 Research Binder Kd: 191 nM Research tool
SBP Info
 		[2]
References
1 Construction of small molecular CTLA4 analogs with CD80-binding affinity. Biochem Biophys Res Commun. 2019 Jun 4;513(3):694-700.
2 Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains. J Mol Biol. 2001 Jul 13;310(3):591-601.