Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00181)
BTS Name
Alpha-crystallin
Synonyms
Acr; 14 kDa antigen; 16 kDa antigen; HSP 16.3; Nox16
BTS Type
Protein
Family
Small heat shock protein (HSP20) family
Gene Name
hspX
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function
Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection.
UniProt ID
P9WMK1
UniProt Entry
ACR_MYCTU
PFam
PF00011
Gene ID
887579
Sequence
MATTLPVQRHPRSLFPEFSELFAAFPSFAGLRPTFDTRLMRLEDEMKEGRYEVRAELPGV
DPDKDVDIMVRDGQLTIKAERTEQKDFDGRSEFAYGSFVRTVSLPVGADEDDIKATYDKG
ILTVSVAVSEGKPTEKHIQIRSTN
Sequence Length
144
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Human VH dAb anti-Acr VH E3(Y391W) Research Binder N.A. Latent tuberculosis [ICD-11: 1B14]
SBP Info
 		[1]
Human VH dAb anti-Acr VH F1(M394E) Research Binder N.A. Latent tuberculosis [ICD-11: 1B14]
SBP Info
 		[1]
scFv anti-TB B4m1 Research Binder N.A. Research tool
SBP Info
 		[2]
scFv anti-TB B4m2 Research Binder N.A. Research tool
SBP Info
 		[2]
scFv anti-TB B4m3 Research Binder N.A. Research tool
SBP Info
 		[2]
References
1 Optimisation of human V H domain antibodies specific to Mycobacterium tuberculosis heat shock protein (HSP16.3). J Comput Aided Mol Des. 2019 Mar;33(3):375-385.
2 Improving the characteristics of a mycobacterial 16 kDa-specific chicken scFv. Biologicals. 2011 Mar;39(2):110-6.