Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00056) | ||||||
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| BTS Name |
Tubulin alpha-1A chain
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| Synonyms |
Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain
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| BTS Type |
Protein
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| Family |
Tubulin family
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| Gene Name |
TUBA1A
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| Organism |
Homo sapiens (Human)
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| Function |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGVDSVEGEGEEEGEEY |
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| Sequence Length |
451
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| alphaRep protein anti-Alpha-tubulin iE5 | Research | Binder | Kd: 270 nM | Research tool | [1] | |
| alphaRep protein anti-Alpha-tubulin iiH5 | Research | Binder | Kd: 95 nM | Research tool | [1] | |
| alphaRep protein anti-Alpha-tubulin iiiA5 | Research | Binder | Kd: 5 nM | Tools for understanding nucleation | [2] | |