General Information of Binding Target of SBP (BTS) (ID: ST00041)
BTS Name
Lymphocyte activation gene 3 protein
Synonyms
LAG-3; CD antigen CD223
BTS Type
Protein
Family
LAG3 family
Gene Name
LAG3
Organism
Homo sapiens (Human)
Function
Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear ; [Secreted lymphocyte activation gene 3 protein]: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.
UniProt ID
P18627
UniProt Entry
LAG3_HUMAN
Gene ID
3902
Sequence
MWEAQFLGLLFLQPLWVAPVKPLQPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRRAG
VTWQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRV
QLDERGRQRGDFSLWLRPARRADAGEYRAAVHLRDRALSCRLRLRLGQASMTASPPGSLR
ASDWVILNCSFSRPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWG
CILTYRDGFNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRLPAGVGTRSFLTAKWTP
PGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAIITVTPKSFGS
PGSLGKLLCEVTPVSGQERFVWSSLDTPSQRSFSGPWLEAQEAQLLSQPWQCQLYQGERL
LGAAVYFTELSSPGAQRSGRAPGALPAGHLLLFLILGVLSLLLLVTGAFGFHLWRRQWRP
RRFSALEQGIHPPQAQSKIEELEQEPEPEPEPEPEPEPEPEPEQL
Sequence Length
525
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Affimer anti-LAG-3 AVA-017 Research Antagonist N.A. Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Affimer anti-PD-L1/LAG-3 AVA-021 Research Inhibitor N.A. Tumors [ICD-11: XH1N44]
SBP Info
[1]
DART Tebotelimab Phase III Inhibitor N.A. Solid tumour/cancer [ICD-11: 2A00-2F9Z]; Heme Malignancies
SBP Info
[2]
References
1 Avacta. Product Development Pipeline. 2021.
2 MacroGenics. Product Development Pipeline. 2021.