Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP003622)
SBP Name
Fab anti-SARS-CoV-2 CC12.3-D02
Synonyms
Fab CC12.3-D02
Molecular Weight 46.7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Sequence Length 435
SBP Sequence
>Heavy chain
QVQLVESGGGLIQPGGSLRLSCKTSGFTVSNTAMAWVRQAPGKGLEWVSAIDASGSQYYA
DSVKGRFTISRDNSKSTLYLQMNSLRVEDTAVYYCARLDYGSAFDYWGQGTLVTVSSAST
KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY
SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
>Light chain
EIVLTQSPGTLSLSPGERATLSCKASQDIGYWLAWYQQKPGQAPRLLIYDGSKLAEGIPD
RFSGSGSGTDFTLTISRLEPEDFAVYYCLQNAEFPPTFGQGTKLEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT
LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS
3D Structure
Computationally Modelled Structure
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Template Name Fab CC12.3
Template Sequence
>Heavy chain
QVQLVESGGGLIQPGGSLRLSCAASGFTVSSNYMSWVRQAPGKGLEWVSVIYSGGSTFYA
DSVKGRFTISRDNSKSTLYLQMNSLRVEDTAVYYCARDFGDFYFDYWGQGTLVTVSSAST
KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY
SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
>Light chain
EIVLTQSPGTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYGASSRATGIPD
RFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPRTFGQGTKLEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT
LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS
Protein Scaffold Information of This SBP
Scaffold ID PS034
Scaffold Info
[1]
Scaffold Name Fab
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Spike glycoprotein
BTS Info
binder SARS-CoV-2 [ICD-11: XN109] N.A. Chulalongkorn University [1]
References
1 Computational redesign of Fab CC12.3 with substantially better predicted binding affinity to SARS-CoV-2 than human ACE2 receptor. Sci Rep. 2021 Nov 12;11(1):22202.