Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP003600)
SBP Name
DARPin anti-HDAC6-ZnF F10
Synonyms
DARPin F10
Molecular Weight 17.1 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method ribosome display
Highest Status Research
PDB ID 7ATT
Sequence Length 162
SBP Sequence
>DARPin anti-HDAC6-ZnF F10
GSDLGKKLLEAARAGQDDEVRILMANGADVNANDRNGVTPLHLAADKGHLEIVEVLLKTG
ADVNAIDIMGATPLHLAAAHGHLEIVEVLLKAGADVNAMDHKGFTPLHLAAWRGHLEIVE
VLLKHGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAAKLN
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS027
Scaffold Info
[1]
Scaffold Name DARPin
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Histone deacetylase 6
BTS Info
Blocker Tools for impairing infection by influenza and Zika virus at the uncoating step Kd: 95.05 nM University of Basel [1]
References
1 Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways. Cell Rep. 2022 Apr 26;39(4):110736.