Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003599) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
scFv anti-hTIGIT MG1131
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| Synonyms |
MG1131-scfv
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| Molecular Weight | 26.8 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| PDB ID | 7VYT | |||||
| Sequence Length | 257 | |||||
| SBP Sequence |
>Heavy chain
MEVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGIINPSGGSTS YAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCASRSGSGWFGALDYWGQGTLVTV SS >Light chain GGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQK PGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPGGTF GQGTKVEIKRVDKLA |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS057 | [1] | ||||
| Scaffold Name | scFv | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| T-cell immunoreceptor with Ig and ITIM domains | Blocker | Tumors [ICD-11: XH1N44] | N.A. | Korea Advanced Institute of Science and Technology | [1] | |