Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00599) | ||||||
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| BTS Name |
T-cell immunoreceptor with Ig and ITIM domains
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| Synonyms |
V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3
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| BTS Type |
Protein
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| Gene Name |
TIGIT
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| Organism |
Homo sapiens (Human)
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| Function |
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWE
QQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTG RIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVVVALTRKKKALRIHSVEGDLR RKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGEDCAELHDYFNVLSYRSLGNCSFF TETG |
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| Sequence Length |
244
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| scFv anti-hTIGIT MG1131 | Research | Blocker | N.A. | Tumors [ICD-11: XH1N44] | [1] | |