Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003530) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Monobody anti-SARS-CoV-2 C4-AM2
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| Synonyms |
Monobody C4-AM2
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| Molecular Weight | 13.4 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli BL21 (DE3) | |||||
| Selection Method | TRAP display | |||||
| Highest Status | Research | |||||
| Sequence Length | 120 | |||||
| SBP Sequence |
>Monobody anti-SARS-CoV-2 C4-AM2
MRHQSHHHHHHTSGTGSLEVVEASPTSIQISWDAPRGGPADYQWVRYYRITYGETGGNSP VQEFTVPGSKSTATISGLKPGVDYTITVYAVTWTGKVPWYWSANPISINYRTEIDKPSQC |
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| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS047 | [1] | ||||
| Scaffold Name | Monobody | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Spike glycoprotein | Neutralizer | COVID-19 [ICD-11: RA01.0] | Kd: <0.01 nM | Nagoya University | [1] | |
| Spike glycoprotein | Neutralizer | COVID-19 [ICD-11: RA01.0] | Kd: 6.3 nM | Nagoya University | [1] | |
| Spike glycoprotein | Neutralizer | COVID-19 [ICD-11: RA01.0] | Kd: 4.4 nM | Nagoya University | [1] | |
| Spike glycoprotein | Neutralizer | COVID-19 [ICD-11: RA01.0] | Kd: 1.7 nM | Nagoya University | [1] | |