General Information of Synthetic Binding Protein (SBP) (ID: SBP003452)
SBP Name
Nanobody anti-SARS-CoV-2 MR4
Synonyms
Nanobody MR4
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Spike glycoprotein
BTS Info
Inhibitor SARS-CoV-2 infection (COVID-19) [ICD-11: XN109] Kd: 23.3 nM Chinese Academy of Sciences (CAS) [1]
References
1 A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.Nat Commun. 2021 Jul 30;12(1):4635.