General Information of Synthetic Binding Protein (SBP) (ID: SBP003442)
SBP Name
Miniprotein anti-SARS-CoV-2 LCB7
Synonyms
Miniprotein LCB7
Molecular Weight 6.9 kDa
Thermal Denaturation TEMP >95 ℃
Design Method de novo protein design
Expression System Escherichia coli
Selection Method Yeast display
Highest Status Research
Sequence Length 57
SBP Sequence
>Miniprotein anti-SARS-CoV-2 LCB7
DDDIRYLIYMAKLRLEQGNPEEAEKVLEMARFLAERLGMEELLKEVRELLRKIEELR
3D Structure
Computationally Modelled Structure
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Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Spike glycoprotein
BTS Info
Inhibitor SARS-CoV-2 infection (COVID-19) [ICD-11: XN109] Kd: 1-20 nM University of Washington [1]
References
1 De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.Science. 2020 Oct 23;370(6515):426-431.