General Information of Synthetic Binding Protein (SBP) (ID: SBP003438)
SBP Name
Miniprotein anti-SARS-CoV-2 LCB3
Synonyms
Miniprotein LCB3
Molecular Weight 7.7 kDa
Design Method de novo protein design
Expression System Escherichia coli
Selection Method Yeast display
Highest Status Research
PDB ID 7JZM
Sequence Length 64
SBP Sequence
>Miniprotein anti-SARS-CoV-2 LCB3
NDDELHMLMTDLVYEALHFAKDEEIKKRVFQLFELADKAYKNNDRQKLEKVVEELKELLE
RLLS
3D Structure
Experimentally Validated Structure
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Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Spike glycoprotein
BTS Info
Inhibitor SARS-CoV-2 infection (COVID-19) [ICD-11: XN109] Kd: <1 nM University of Washington [1]
References
1 De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.Science. 2020 Oct 23;370(6515):426-431.