General Information of Synthetic Binding Protein (SBP) (ID: SBP003418)
SBP Name
Affimer anti-Fc-gamma-RIIIA G3
Synonyms
Affimer G3
Molecular Weight 11.5 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Phage display
Highest Status Research
PDB ID 5MN2
Sequence Length 101
SBP Sequence
>Affimer anti-Fc-gamma-RIIIA G3
ATGVRAVPGNENSLEIEELARFAVDEHNKKENALLEFVRVVKAKEQAMNTGFTLATMYYL
TLEAKDGGKKKLYEAKVWVKNTQWHNAMTNFKELQEFKPVG
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS006
Scaffold Info
[1]
Scaffold Name Affimer
Scaffold Class Non-Antibody
Fold Type One Alpha-Helix + Beta-Sheets+ Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Fc-gammaRIIIA
BTS Info
Blocker Research tool Kd: 2600 nM University of Leeds [1]
References
1 Affimer proteins inhibit immune complex binding to FcRIIIa with high specificity through competitive and allosteric modes of action. Proc Natl Acad Sci USA. 2018 Jan 2;115(1):E72-E81.