Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP003383) | ||||||
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SBP Name |
scFv Oportuzumab
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Synonyms |
VB-4847; VB-845; VB4-845
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Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Highest Status | Preregistration | |||||
SBP Sequence |
>VH Chain
EVQLVQSGPGLVQPGGSVRISCAASGYTFTNYGMNWVKQAPGKGLEWMGWINTYTGESTY ADSFKGRFTFSLDTSASAAYLQINSLRAEDTAVYYCARFAIKGDYWGQGTLLTVSS >VL Chain DIQMTQSPSSLSASVGDRVTITCRSTKSLLHSNGITYLYWYQQKPGKAPKLLIYQMSNLA SGVPSRFSSSGSGTDFTLTISSLQPEDFATYYCAQNLEIPRTFGQGTKVELK |
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Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS057 | [1] | ||||
Scaffold Name | scFv | |||||
Scaffold Class | Antibody fragment | |||||
Fold Type | Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Epithelial cell adhesion molecule | Binder | Bladder cancer [ICD-11: 2C94.Z]; Head and neck cancer | N.A. | Sesen Bio | [1] | |
Clinical Trial Information of This SBP | ||||||
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NCT03258593 | Click to show the Detail | |||||
Indication | High-Grade Non-Muscle-Invasive Bladder Cancer | |||||
Phase | Phase I | |||||
Title | A Phase I Single-Arm Study of the Combination of Durvalumab (MEDI4736) and Vicineum (Oportuzumab Monatox, VB4-845) in Subjects With High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated With Bacillus Calmette-Gu(SqrRoot)(Copyright)Rin (BCG) | |||||
Status | Recruiting | |||||
Sponsor | National Cancer Institute (NCI) | |||||
NCT04859751 | Click to show the Detail | |||||
Indication | Non-Muscle Invasive Bladder Cancer | |||||
Phase | Phase III | |||||
Title | Study of VB4-845 Injection for Treating Patients With Non-muscle Invasive Bladder Cancer | |||||
Status | Unknown status | |||||
Sponsor | Qilu Pharmaceutical Co., Ltd. | |||||