General Information of Synthetic Binding Protein (SBP) (ID: SBP003140)
SBP Name
Nanobody anti-VEGF
Synonyms
VEGF nanobody
Molecular Weight 15 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli WK6
Selection Method Docking simulation experiments
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Vascular endothelial growth factor A
BTS Info
Inhibitor Cancers [ICD-11: 2D4Z] N.A. Pasteur Institute of Iran [1]
References
1 A nanobody-derived mimotope against VEGF inhibits cancer angiogenesis. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1233-1239.