Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP003139)
SBP Name
Monobody BMS-986192
Synonyms
Monobody BMS-986192
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS047
Scaffold Info
[1] , [2]
Scaffold Name Monobody
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Programmed cell death 1 ligand 1
BTS Info
Binder Molecular imaging of PD-L1 expression N.A. University of Groningen [1] , [2]
Clinical Trial Information of This SBP
NCT03520634 Click to show the Detail
Indication Melanoma
Phase Not Applicable
Title PD-L1 PET Imaging in Melanoma Patients
Status Completed
Sponsor University Medical Center Groningen
NCT03843515 Click to show the Detail
Indication Oral Cavity Squamous Cell Carcinoma
Phase Phase I
Title Safety and tolerability of neoadjuvant nivolumab for locally advanced resectable oral cancer, combined with [18F]BMS-986192 / [18F]-FDG PET imaging and immunomonitoring for response prediction
Status Recruiting
Sponsor VU University Medical Center
References
1 Synthesis and Preclinical Evaluation of 68 Ga-labeled Adnectin, 68 Ga-BMS-986192 as a PET Agent for Imaging PD-L1 Expression. J Nucl Med. 2021 Jan 30;jnumed.120.258384.
2 Application of the Gyrolab microfluidic platform to measure picomolar affinity of a PD-L1-binding Adnectin? radioligand for positron emission tomography. Biotechniques. 2020 Sep;69(3):200-205.