Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP003133) | ||||||
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SBP Name |
Monobody anti-SARS-CoV-2 FN3C
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Synonyms |
Monobody FN3C
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Molecular Weight | 11.0 kDa | |||||
Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Expression System | Escherichia coli | |||||
Selection Method | Phage display | |||||
Highest Status | Research | |||||
Sequence Length | 97 | |||||
SBP Sequence |
>Monobody anti-Spik RBD FN3S
MAVSDVPRKLEVVAATPTSLLISWDYYSYSYNYYRITYGETGGNSPVQEFTVPGYYYTAT ISGLKPGVDYTITVYAVTLYGPGYYYYYPGISINYRT |
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3D Structure | ||||||
Computationally Modelled Structure | ||||||
Click to Save PDB File | ||||||
Template Name | Fibronectin type III domain (FN3) | |||||
Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS047 | [1] | ||||
Scaffold Name | Monobody | |||||
Scaffold Class | Non-Antibody | |||||
Fold Type | Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Spike glycoprotein | Binder | SARS-CoV-2 infection (COVID-19) [ICD-11: XN109] | Kd: 14 nM | Tango Biosciences, Inc | [1] | |