General Information of Synthetic Binding Protein (SBP) (ID: SBP003077)
SBP Name
scFv anti-IL-21R Random-15
Synonyms
scFv Random-15
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Yeast display
Highest Status Research
SBP Sequence
>Heavy Chain
QVQLVQSGGGVVQPGRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGSNKNF
ADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDLSHTIRLGNWFDPWGQGTLVT
VSSA
>Light Chain
EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPA
RFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPTFGQGTKVEIK
Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Interleukin-21 receptor
BTS Info
Binder Research tool Kd: 1.9 nM GigaGen Inc [1]
References
1 A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library. MAbs. 2018 Apr;10(3):431-443.