General Information of Synthetic Binding Protein (SBP) (ID: SBP001767)
SBP Name
scFv anti-pre-S1 1E4
Synonyms
scFv 1E4
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Surface plasmon resonance
Highest Status Research
SBP Sequence
>VH
QVQLVQSGGGLVKPGGSLRLSCEASGFPFRDAWMTWVRQAPGRGLEWVGRIKKKSDGGAT
DYAASVKDRFTISRDDSKNMLWLQMNSLKVEDTAVYYCTRSVSSWYEYFYYYYMDLWGKG
TTVTVSS
Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Large envelope protein
BTS Info
Inhibitor Hepatitis B virus infection [ICD-11: XN0GA] Kd: 258 nM Inje University [1]
References
1 Improvement of neutralizing activity of human scFv antibodies against hepatitis B virus binding using CDR3 V(H) mutant library. Viral Immunol. Spring 2006;19(1):115-23.