Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001765)
SBP Name	scFv anti-HBV PreS1/TACE A9
Synonyms	scFv PreS1/TACE A9
Molecular Weight	30 kDa
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli BL21 (DE3)
Selection Method	Phage display
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS057 Scaffold Info					[1] , [2]
Scaffold Name	scFv
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Large envelope protein	BTS Info	Binder	Hepatitis B virus infection [ICD-11: XN0GA]	Kd: 176 nM	Inje University; University of Cambridge	[1] , [2]
Disintegrin and metalloproteinase domain-containing protein 17	BTS Info	Binder	Hepatitis B virus infection [ICD-11: XN0GA]	Kd: 90 nM	Inje University; University of Cambridge	[1] , [2]

References

1	Improvement of neutralizing activity of human scFv antibodies against hepatitis B virus binding using CDR3 V(H) mutant library. Viral Immunol. Spring 2006;19(1):115-23.
2	Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy. Protein Eng Des Sel. 2014 Jun;27(6):179-90.