General Information of Synthetic Binding Protein (SBP) (ID: SBP001747)
SBP Name
scFv anti-DNA-polymerase G2
Synonyms
scFv G2
Molecular Weight 25.3 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli TG1
Selection Method Ribosome display
Highest Status Research
Sequence Length 238
SBP Sequence
>scFv anti-DNA-polymerase G2
EVQLEQSGPSLVEPSQTLSLTCSVTGDSITSGYWNWIRKLPGNKLEYMGYISYSGSTYYN
PSLKSRISITRDTSKNRYYLQLNSVTTEDTATYYCARQLGTYWGQGTTVTVSSGGGGSGG
GGSGGGGSDVELTQSPAAMSASPGEKVTMTCRASSSVSSSYLHWYQQRSGASPKLWIYST
SNLASGVPARFSGSGSGTSYSLTINSVEAEDAATYYCQQYSGYPLTFGAGTKLELKRA
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Protein P
BTS Info
Binder Hepatitis B virus infection [ICD-11: XN0GA] Kd: 3.3 nM Ajou University; University of Hamburg [1]
References
1 Selection of scFvs specific for HBV DNA polymerase using ribosome display. J Immunol Methods. 2004 Jan;284(1-2):147-57.