General Information of Synthetic Binding Protein (SBP) (ID: SBP001711)
SBP Name
scFv anti-RVGp RB156
Synonyms
scFv RB156
Molecular Weight 31 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli BL21 (DE3)
Selection Method Ribosome display
Highest Status Research
SBP Sequence
>VH Chain
QVQLQESGAEVKKPGSSVKVSCRASGDTFNIYAFSWVRQAPGQGLEWMGRIIPFLGTVNY
AQNCQGRATITADKSTSTAYMYLSGLRFDDTAVYYCARCSYSNYYYYGMDVWGQGTLVTV
SS
>VL Chain
DIQMTQSPSTLSASVGDRVTITCRASHNINSWLAWYQQRPGKAPKLLIYKASSLESGVPS
RFSGSGAGTDFNLTISSPQPDDFAAYYCQDFNYPWTFGQGTKVEIKRTVAA
Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Glycoprotein
BTS Info
Binder Rabies virus infection [ICD-11: XN796] Kd: 1.9 nM Academy of Military Medical Sciences [1]
References
1 Selection and affinity maturation of human antibodies against rabies virus from a scFv gene library using ribosome display. J Biotechnol. 2009 Dec;144(4):253-8.