Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00158)
BTS Name
Glycoprotein
BTS Type
Protein
Family
Lyssavirus glycoprotein family
Gene Name
G
Organism
Rabies virus (strain ERA) (RABV)
Function
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
UniProt ID
P03524
UniProt Entry
GLYCO_RABVE
PFam
PF00974
Sequence
MVPQALLFVPLLVFPLCFGKFPIYTILDKLGPWSPIDIHHLSCPNNLVVEDEGCTNLSGF
SYMELKVGYILAIKMNGFTCTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWK
MAGDPRYEESLHNPYPDYRWLRTVKTTKESLVIISPSVADLDPYDRSLHSRVFPSGKCSG
VAVSSTYCSTNHDYTIWMPENPRLGMSCDIFTNSRGKRASKGSETCGFVDERGLYKSLKG
ACKLKLCGVLGLRLMDGTWVAMQTSNETKWCPPDQLVNLHDFRSDEIEHLVVEELVRKRE
ECLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEILPS
KGCLRVGGRCHPHVNGVFFNGIILGPDGNVLIPEMQSSLLQQHMELLESSVIPLVHPLAD
PSTVFKDGDEAEDFVEVHLPDVHNQVSGVDLGLPNWGKYVLLSAGALTALMLIIFLMTCC
RRVNRSEPTQHNLRGTGREVSVTPQSGKIISSWESHKSGGETRL
Sequence Length
524
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Diabody anti-RVGp D06 Research Binder N.A. Rabies [ICD-11: 2A22]
SBP Info
 		[1]
scFv anti-RVGp 50AD1 Research Inhibitor N.A. Research tool
SBP Info
 		[2]
scFv anti-RVGp RB109 Research Binder Kd: 1.9 nM Rabies virus infection [ICD-11: XN796]
SBP Info
 		[3]
scFv anti-RVGp RB156 Research Binder Kd: 1.9 nM Rabies virus infection [ICD-11: XN796]
SBP Info
 		[3]
scFv anti-RVGp RB24 Research Binder Kd: 5.5 nM Rabies virus infection [ICD-11: XN796]
SBP Info
 		[3]
scFv anti-RVGp RB71 Research Binder Kd: 1.7 nM Rabies virus infection [ICD-11: XN796]
SBP Info
 		[3]
scFv anti-RVGp S104 Research Binder Kd: 4.2 nM Rabies virus infection [ICD-11: XN796]
SBP Info
 		[3]
References
1 A novel in vitro ELISA for estimation of glycoprotein content in human rabies vaccines. J Immunoassay Immunochem. 2017;38(4):400-410.
2 Recombinant single-chain Fv antibody fragment-alkaline phosphatase conjugate: a novel in vitro tool to estimate rabies viral glycoprotein antigen in vaccine manufacture. J Virol Methods. 2007 Dec;146(1-2):246-56.
3 Selection and affinity maturation of human antibodies against rabies virus from a scFv gene library using ribosome display. J Biotechnol. 2009 Dec;144(4):253-8.