General Information of Synthetic Binding Protein (SBP) (ID: SBP001689)
SBP Name
scFv anti-HBV clone 3
Synonyms
scFv-3
Molecular Weight 26 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Escherichia coli display
Highest Status Research
SBP Sequence
>VH CDR1
GFIFSGSSLH
>VH CDR2
RIRPRADNYATAYAASMKG
>VH CDR3
IVPKCQIT
>VL CDR1
RASQGISSWLA
>VL CDR2
GASTLQN
>VL CDR3
QNKKQNKNV
Template Name ScFv-31
Template Sequence
>VH CDR1
GFIFSGSSLH
>VH CDR2
RIRPRADNYATAYAASMKG
>VH CDR3
FDWGTSLI
>VL CDR1
RASQGISSWLA
>VL CDR2
GASTLQN
>VL CDR3
QQAYSFPYT
Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1] , [2]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Large envelope protein
BTS Info
Neutralizer Hepatitis B virus infection [ICD-11: XN0GA]; Other specified acute pancreatitis [ICD-11: DC31.Y] N.A. Northeast Agricultural University [1] , [2]
Infectious pancreatic necrosis virus ChRtm213
BTS Info
Neutralizer Hepatitis B virus infection [ICD-11: XN0GA]; Other specified acute pancreatitis [ICD-11: DC31.Y] N.A. Northeast Agricultural University [1] , [2]
References
1 Selection of affinity-improved neutralizing human scFv against HBV PreS1 from CDR3 VH/VL mutant library. Biologicals. 2016 Jul;44(4):271-275.
2 Recombinant scFv antibodies against infectious pancreatic necrosis virus isolated by flow cytometry. J Virol Methods. 2016 Nov;237:204-209.