Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP001634) | ||||||
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SBP Name |
scFv anti-GPNMB G49
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Synonyms |
scFv G49
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Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Expression System | Escherichia coli BL21 (DE3) | |||||
Selection Method | Phage display | |||||
Highest Status | Research | |||||
SBP Sequence |
>VH Chain
QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANY AQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARGPNTWGQGTLVTV >VL Chain LDVVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKPGQSPQLLIYLGSNR ASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQALQTHPTEGQGTKVEIKR |
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Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS057 | [1] | ||||
Scaffold Name | scFv | |||||
Scaffold Class | Antibody fragment | |||||
Fold Type | Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Transmembrane glycoprotein NMB | Binder | Glioma [ICD-11: 2A00.0] | Kd: 8.4 nM | Duke University Medical Center | [1] | |